Trogarzo

The recently published AMP trial (HVTN 703/HPTN 081 and HVTN704/HPTN 085) results have validated broad neutralising antibodies (bNAbs) as potential anti-HIV-1 agents. However, single bNAb preparations are unlikely to cope with the onslaught of existing and de novo resistance mutations, thus necessitating the use of bNAb combinations to achieve clinically relevant results. Specifically, engineered antibodies […]

Given the high variability and drug-resistance problem by human immunodeficiency virus type 1 (HIV-1), the development of bispecific or multi-specific inhibitors targeting different steps of HIV entry is highly appreciated. We previously generated a very potent short-peptide-based HIV fusion inhibitor 2P23. In this study, we designed and characterized a bifunctional inhibitor termed 2P23-iMab by genetically

Previous SPECT and PET semi-quantitative in vivo imaging studies in monkeys have demonstrated specific uptake of radiolabeled rhesus recombinant anti-CD4 monoclonal antibody fragment CD4R1-F(ab΄)2 in the spleen and clusters of lymph nodes (LNs) but yielded conflicting results of imaging the gut CD4 + T-cell pool. Here, using PET dynamic imaging with kinetic analysis, we performed a fully quantitative

Treatment of multidrug-resistant HIV-2 is an emerging issue, because of the rapid selection of mutations at time of virological failure and the low number of antiretrovirals active on HIV-2. The aim of this study was to determine the susceptibility of HIV-2 primary isolates to ibalizumab, a long-acting monoclonal antibody that binds to CD4 that is approved for the treatment of MDR

While there are increased opportunities for transplant, PWH have added layers of complexity relating to resistance profiles and drug-drug interactions (DDIs) between their antiretroviral (ARV) regimen and the immunosuppressive medications required to prevent organ rejection. • Ibalizumab (IBA), a CD4-directed post-attachment HIV-1 inhibitor, received US approval in 2018 as the first long-acting antiretroviral and monoclonal

For most patients, the durability of virologic response was maintained with minimal adjustments to the OBR. Altogether, these data demonstrate the contribution of IBA towards durable viral suppression in TE HIV patients with limited therapeutic options.

Subgroup analyses of TMB-301/311 data show significant efficacy of IBA among patients with one or two other fully active agents, with durable responses regardless of the number of active agents. Patients who combined IBA with DTG showed impressive rates of suppression. Data support the long-term efficacy of IBA-based regimens that include two or three fully

Ibalizumab is the first long-acting antiretroviral and monoclonal antibody approved for the treatment of HIV-1 infection. With no expected DDIs or cross-resistance with other ARVs, it became a key option for this patient.

In patients with MDR HIV-1 infection who had advanced disease and limited treatment options, ibalizumab had significant antiviral activity during a 25-week study. Evidence of the emergence of diminished ibalizumab susceptibility was observed in vitro in patients who had virologic failure.